Description

Dimethindene is a potent, selective histamine H1-receptor antagonist belonging to the alkylamine class of antihistamines. This compound is of significant commercial and pharmaceutical importance due to its efficacy in blocking allergic responses. It is primarily utilized in the development and manufacturing of pharmaceutical formulations for the treatment of allergic conditions such as rhinitis, conjunctivitis, and urticaria. Global suppliers and manufacturers in the active pharmaceutical ingredient (API) sector rely on high-purity Dimethindene to ensure the safety and efficacy of final medicinal products.

Application

• Pharmaceutical API: Primary active ingredient in anti-allergy medications, including tablets, syrups, and topical creams.
• Veterinary Medicine: Used in formulations to manage allergic reactions and pruritus in animals.
• Research & Development: Valuable reference standard and biochemical tool for pharmacological studies on histamine receptors and allergic pathways.
• Combination Therapies: Incorporated into multi-active drug formulations for enhanced symptomatic relief of colds and allergies.
• Dermatological Preparations: Key component in gels and ointments designed to relieve itching and skin inflammation.

Basic Information

Product Name	Dimethindene
CAS No.	5636-83-9
Molecular Formula	C20H24N2
Molecular Weight	292.42 g/mol
Synonyms	Dimethindene Maleate (common salt form); Dimethindene Maleate Salt; 2-[1-[2-(2-Dimethylaminoethyl)-3-indenyl]ethyl]pyridine; Dimethinden; Dimethindenum; Fenistil (trade name); Foristal; Dimethindene Base
EINECS	227-076-8

Quality Control

Our Dimethindene is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and other pharmacopeial methods. We provide full traceability and support regulatory submissions with detailed documentation. Certificates of Analysis (COA) confirming compliance with in-house specifications, and relevant pharmacopeial monographs where applicable, are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.