Description

Betamethasone 17,21-Dipropionate is a potent synthetic corticosteroid ester, widely recognized for its enhanced topical anti-inflammatory and immunosuppressive activity. This compound is a critical active pharmaceutical ingredient (API) and intermediate in the production of advanced dermatological and ophthalmic formulations. It is essential for manufacturers in the pharmaceutical industry developing creams, ointments, and lotions for treating severe skin conditions such as psoriasis, eczema, and dermatitis. Its efficacy and stability profile make it a cornerstone in specialized steroid therapies.

Application

• Topical Corticosteroid Formulations: Primary API in prescription-strength creams, ointments, gels, and lotions for treating inflammatory skin disorders.
• Ophthalmic Preparations: Used in eye drops and ointments to manage inflammation following ocular surgery or due to conditions like uveitis.
• Veterinary Pharmaceuticals: Incorporated into topical treatments for dermatological conditions in animals.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate for further chemical modification into other specialized corticosteroid derivatives.
• Research & Development: Utilized in biochemical research to study glucocorticoid receptor activity and anti-inflammatory mechanisms.
• Compounding Pharmacy: A critical ingredient for custom-formulated medications tailored to specific patient needs in dermatology.

Basic Information

Product Name	Betamethasone 17,21-Dipropionate
CAS No.	5593-20-4
Molecular Formula	C28H37FO7
Molecular Weight	504.59 g/mol
Synonyms	Betamethasone Dipropionate; 9α-Fluoro-16β-methylprednisolone 17,21-dipropionate; Diprolene (trade name); Betnovate (trade name); (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate; Betamethasone 17-propionate 21-propionate; Sch 1158
EINECS	227-007-1

Quality Control

Our Betamethasone 17,21-Dipropionate is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including HPLC for assay and impurity profiling, residual solvent analysis, and specific identification tests. A Certificate of Analysis (COA) documenting purity, related substances, and other critical parameters is provided with every shipment to ensure full traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Water (Karl Fischer)	≤ 1.0% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	+88° to +94° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.