Description

2-Bromo-3,4,5,6-Tetrafluoronitrobenzene is a highly functionalized fluorinated aromatic building block, valued for its unique combination of halogen and electron-withdrawing groups. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty materials industries for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the fluorine and bromine substituents contribute to biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic components in electronic materials, influencing dielectric properties and molecular alignment.
• Polymer Modification: Employed to introduce fluorinated phenyl groups into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of the bromine atom, enabling the construction of complex biaryl structures.
• Organic Synthesis & Chemical Research: A valuable reagent for exploring novel nucleophilic aromatic substitution (SNAr) pathways and developing new fluorination methodologies.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluoronitrobenzene
CAS No.	5580-83-6
Molecular Formula	C6BrF4NO2
Molecular Weight	273.97 g/mol
Synonyms	1-Bromo-2,3,4,5-tetrafluoro-6-nitrobenzene; Benzene, 2-bromo-3,4,5,6-tetrafluoro-1-nitro-; 2,3,4,5-Tetrafluoro-6-nitrobenzyl Bromide (incorrect but common search variant); 2-Bromo-1,3,4,5-tetrafluoro-6-nitrobenzene; Pentafluoronitrobenzene, bromo derivative; Nitroperfluorobromobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4,5,6-Tetrafluoronitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specification parameters are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.