Description

2,3,4,5-Tetrafluoronitrobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring a nitro group flanked by fluorine atoms, makes it a critical intermediate for the development of complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for creating novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated liquid crystals and organic semiconductors used in display technologies and electronic devices.
• Functional Dye & Pigment Manufacturing: Employed in the synthesis of specialized dyes and pigments with improved lightfastness and chemical resistance.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups make it highly reactive in SNAr reactions for introducing diverse functional groups.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new reaction pathways in fluoroorganic chemistry.

Basic Information

Product Name	2,3,4,5-Tetrafluoronitrobenzene
CAS No.	5580-79-0
Molecular Formula	C6HF4NO2
Molecular Weight	195.07 g/mol
Synonyms	1,2,3,4-Tetrafluoro-5-nitrobenzene; Nitro-1,2,3,4-tetrafluorobenzene; Benzene, 1,2,3,4-tetrafluoro-5-nitro-; 2,3,4,5-Tetrafluoro-1-nitrobenzene; 5-Nitro-1,2,3,4-tetrafluorobenzene; NSC 88448; Tetrafluoronitrobenzene (mixed isomers)
EINECS	226-966-7

Quality Control

Our 2,3,4,5-Tetrafluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.