Description

Beclomethasone 17-Propionate is a high-purity synthetic corticosteroid ester, a key pharmaceutical intermediate and active pharmaceutical ingredient (API). Its primary commercial value lies in its potent anti-inflammatory and immunosuppressive properties, making it a critical component in advanced respiratory and dermatological formulations. This compound is essential for manufacturers in the pharmaceutical industry developing inhaled corticosteroids for asthma and COPD, as well as topical treatments for various skin conditions.

Application

• Primary Active Pharmaceutical Ingredient (API) in metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) for asthma and chronic obstructive pulmonary disease (COPD) management.
• Key intermediate in the synthesis of final beclomethasone dipropionate, a widely prescribed corticosteroid.
• Research and development of novel topical corticosteroid creams and ointments for eczema, psoriasis, and dermatitis.
• Manufacturing of nasal sprays for the treatment of allergic and non-allergic rhinitis.
• Reference standard in analytical laboratories for quality control and method development.
• Starting material for process chemistry and custom synthesis of specialized steroid derivatives.

Basic Information

Product Name	Beclomethasone 17-Propionate
CAS No.	5534-18-9
Molecular Formula	C28H37ClO7
Molecular Weight	521.04 g/mol
Synonyms	9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; Beclometasone 17-propionate; 17-Monopropionylbeclomethasone; NSC-107679; 17-Propionylbeclomethasone; Beclomethasone 17-propanoate; 9α-Chloro-16β-methyl-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 17-propionate
EINECS	226-886-1

Quality Control

Our Beclomethasone 17-Propionate is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical intermediate use. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy. While we offer various grades, our standard product is characterized by high chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, and we can support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.