Description

Betamethasone 17-Butyrate is a potent synthetic corticosteroid ester, widely recognized for its enhanced topical anti-inflammatory and antipruritic activity. This compound is a critical active pharmaceutical ingredient (API) for the formulation of high-efficacy dermatological treatments. It is primarily utilized by pharmaceutical manufacturers and R&D institutions in the development of creams, ointments, and lotions for managing inflammatory skin conditions such as eczema, psoriasis, and dermatitis.

Application

• Topical Corticosteroid Formulations: Primary API in creams, ointments, gels, and lotions for treating inflammatory and pruritic manifestations of dermatoses.
• Dermatological R&D: Key reference standard and intermediate in the research and development of new topical steroid therapies.
• Veterinary Medicine: Used in topical preparations for managing skin inflammation and allergic reactions in animals.
• Compounding Pharmacy: Sourced by specialized pharmacies for the preparation of custom dermatological medications.

Basic Information

Item	Details
Product Name	Betamethasone 17-Butyrate
CAS No.	5534-14-5
Molecular Formula	C₂₆H₃₅FO₆
Molecular Weight	462.55 g/mol
Synonyms	Betamethasone 17-Butyrate; Betamethasone Butyrate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-butyrate; Betnovate (as part of formulation); Celestoderm-V (as part of formulation); Betamethasone 17-valerate analog; U-40562
EINECS	226-881-5

Quality Control

Our Betamethasone 17-Butyrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and compliance with relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.