Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is a synthetic corticosteroid derivative, specifically a fluorinated and esterified pregnadiene. This compound is a crucial pharmaceutical intermediate in the synthesis of potent topical anti-inflammatory and anti-pruritic medications. It is primarily required by pharmaceutical manufacturers and research organizations engaged in the development and production of advanced dermatological and ophthalmic treatments.

Application

• Key Intermediate for the synthesis of Fluticasone Propionate, a high-potency glucocorticoid.
• Active Pharmaceutical Ingredient (API) manufacturing for topical creams, ointments, and nasal sprays.
• Research & Development of novel corticosteroid-based therapies with enhanced receptor affinity.
• Dermatological Preparations for treating conditions like eczema, psoriasis, and allergic dermatitis.
• Ophthalmic Solutions for managing inflammatory eye conditions.
• Veterinary Pharmaceutical applications in anti-inflammatory formulations.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate
CAS No.	5534-13-4
Molecular Formula	C25H31FO6
Molecular Weight	446.51 g/mol
Synonyms	Fluticasone Propionate EP Impurity C; Fluticasone Propionate Related Compound C; S-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate; 6,9-Difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate (common misnomer); 9-Fluoro-11β-hydroxy-16β-methyl-3,20-dioxopregna-1,4-diene-17β-yl propionate; 16β-Methyl-9α-fluoro-δ1,4-pregnadiene-11β,17α,21-triol-3,20-dione 17-propionate.
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Propionate is manufactured under strict quality systems. We offer material compliant with pharmaceutical intermediate standards, with typical purity ≥98% (by HPLC). Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be tailored to meet EP/USP monograph requirements for related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.