Description

9-Chloro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Propionate is a high-purity synthetic corticosteroid derivative, also known as Clocortolone Pivalate. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of advanced topical and systemic corticosteroid medications.

Application

• Active Pharmaceutical Ingredient (API) synthesis for corticosteroid drugs.
• Pharmaceutical Research & Development for novel anti-inflammatory formulations.
• Key intermediate in the production of Clocortolone Pivalate and related steroid analogs.
• Development of topical creams, ointments, and lotions for dermatological conditions.
• Preclinical and clinical studies targeting immune-mediated disorders.
• Manufacturing of high-potency corticosteroid products under GMP conditions.

Basic Information

Product Name	9-Chloro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Propionate
CAS No.	5534-08-7
Molecular Formula	C₂₈H₃₇ClO₇
Molecular Weight	521.04 g/mol
Synonyms	Clocortolone Pivalate; Clocortolone Trimethylacetate; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-pivalate; Clocortolone 21-acetate 17-pivalate; SQ-15102; NSC-92338; Clocortolone 17-pivalate 21-acetate; 9α-Chloro-16β-methylprednisolone 17-pivalate 21-acetate
EINECS	226-884-6

Quality Control

Our 9-Chloro-11β,17,21-Trihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione 21-Acetate 17-Propionate is manufactured under strict quality systems. We provide material that meets high-purity pharmaceutical intermediate standards, with specifications tailored for GMP synthesis. Comprehensive analytical testing, including HPLC, is performed to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is supplied with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.