Description

Betamethasone 21-Acetate-17-Propionate is a synthetic glucocorticoid corticosteroid, specifically a diester derivative of betamethasone. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical intermediate in the synthesis of advanced topical and injectable pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for dermatological conditions, allergic reactions, and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of high-potency topical corticosteroids.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of finished dosage forms such as creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Veterinary Medicine: Employed in formulations for treating inflammatory and allergic skin conditions in animals.
• Research & Development: Serves as a reference standard and a building block in medicinal chemistry research for novel steroid-based therapies.
• Dermatological Preparations: A critical component in compounding pharmacies for customized topical treatments.

Basic Information

Item	Details
Product Name	Betamethasone 21-Acetate-17-Propionate
CAS No.	5514-81-8
Molecular Formula	C₂₈H₃₇FO₇
Molecular Weight	504.59 g/mol
Synonyms	Betamethasone 17-propionate 21-acetate; 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate 17-propionate; Betamethasone Acetate Propionate; Betamethasone 17-Propionate-21-Acetate; NSC-119265; SQ-15102; Flubenisolone 21-acetate 17-propionate
EINECS	226-864-4

Quality Control

Our Betamethasone 21-Acetate-17-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, consistent with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP, ISO, and other relevant regulatory standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.