Description

Phenindamine Hydrochloride CAS NO 5503-08-2 is a pharmaceutical-grade antihistamine compound belonging to the class of alkylamine derivatives. It is valued for its specific pharmacological activity in blocking H1 histamine receptors, which is critical for developing therapeutic formulations. This active pharmaceutical ingredient (API) is primarily required by pharmaceutical manufacturers and research institutions for the development and production of anti-allergy medications and related clinical research.

Application

• Primary Active Pharmaceutical Ingredient (API) in oral antihistamine formulations.
• Key intermediate in the synthesis of advanced anti-allergic and antipruritic drugs.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Research chemical for pharmacological studies targeting histamine-mediated pathways.
• Component in preclinical and clinical trial materials for allergy and dermatology research.
• Used in the development of combination therapies for cold and flu symptom relief.

Basic Information

Item	Details
Product Name	Phenindamine Hydrochloride
CAS No.	5503-08-2
Molecular Formula	C19H19N•HCl
Molecular Weight	289.82 g/mol
Synonyms	Phenindamine HCl; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine hydrochloride; Thephorin Hydrochloride; Phenindaminum Chloride; 1-Phenyl-2,3-dihydro-3-methyl-9H-indeno[2,1-c]pyridine hydrochloride; N-(1-Phenylethyl)isoindoline hydrochloride; RP 3277
EINECS	226-846-9

Quality Control

Our Phenindamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.