Description

10,11-Dimethoxy-19α-Methyl-18-Oxayohimban-16β-Carboxylic Acid Methyl Ester is a complex, high-purity indole alkaloid derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate for the development of novel therapeutic agents targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of specialized bioactive molecules.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the research and development of new drug candidates, particularly those with neurological activity.
• Alkaloid Chemistry Research: Used in academic and industrial laboratories for studying structure-activity relationships (SAR) within the yohimbane and related alkaloid families.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Precursor for Medicinal Chemistry: Provides a sophisticated scaffold for the semi-synthesis of analogs with potential pharmacological properties.
• Process Chemistry Development: Used in scaling up synthetic routes for potential active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	10,11-Dimethoxy-19α-Methyl-18-Oxayohimban-16β-Carboxylic Acid Methyl Ester
CAS No.	5308-79-2
Molecular Formula	C23H28N2O5
Molecular Weight	412.48 g/mol
Synonyms	Methyl 10,11-dimethoxy-19α-methyl-18-oxayohimban-16β-carboxylate; 16β-Carbomethoxy-10,11-dimethoxy-19α-methyl-18-oxayohimban; 18-Oxayohimban-16β-carboxylic acid, 10,11-dimethoxy-19α-methyl-, methyl ester; Yohimbane derivative 5308-79-2; Alstonine derivative intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development under GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.