Description

Tetrahydropapaverine Hydrochloride is a synthetic alkaloid derivative and a key intermediate in pharmaceutical research and development. This compound is valued for its role as a precursor in the synthesis of more complex bioactive molecules, particularly those targeting neurological pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process chemistry, and analytical method development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential therapeutic agents and reference standards.
• Neurological Research: Used in preclinical studies investigating compounds that interact with neurotransmitter systems.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing routes.
• Analytical Standard: Employed as a high-purity reference standard for quality control (QC) and method validation in analytical laboratories.
• Chemical Synthesis: Utilized in organic synthesis for the preparation of novel papaverine analogs and other specialized fine chemicals.

Basic Information

Product Name	Tetrahydropapaverine Hydrochloride
CAS No.	6429-04-5
Molecular Formula	C20H25NO4·HCl
Molecular Weight	379.88 g/mol
Synonyms	THP HCl; 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride; Laudanosine Hydrochloride (impurity); Norlaudanosine Hydrochloride; Tetrahydropapaverine HCl; Papaverine Tetrahydrochloride (common misnomer); 6,7-Dimethoxy-1-veratryl-1,2,3,4-tetrahydroisoquinoline Hydrochloride
EINECS	229-213-3

Quality Control

Our Tetrahydropapaverine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.