Description

Cinchonine CAS NO 118-10-5 is a naturally occurring alkaloid, a stereoisomer of cinchonidine, primarily extracted from the bark of *Cinchona* trees. This compound serves as a critical chiral building block and resolving agent in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and manufacturing in the pharmaceutical, agrochemical, and specialty chemical industries, where precise stereochemistry is paramount for product efficacy and safety.

Application

• Asymmetric Synthesis & Catalysis: Employed as a chiral ligand, base, or organocatalyst in stereoselective reactions.
• Pharmaceutical Intermediates: A key starting material and resolving agent for the synthesis of active pharmaceutical ingredients (APIs), particularly antimalarial and antiarrhythmic drugs.
• Analytical Chemistry: Used in chiral chromatography as a stationary phase modifier or as a standard for method development.
• Biochemical Research: Investigated for its biological activity and used as a tool compound in pharmacological studies.
• Fine Chemical Production: Integral in the manufacture of high-value, optically active compounds for agrochemicals and flavors/fragrances.

Basic Information

Product Name	Cinchonine
CAS No.	118-10-5
Molecular Formula	C19H22N2O
Molecular Weight	294.39 g/mol
Synonyms	(8α,9R)-Cinchonan-9-ol; Cinchonan-9-ol, (8α,9R)-; (9R)-Cinchonine; Cinchotine; α-Cinchonine; LA2; (-)-Cinchonine; Cinchonine, (-)-
EINECS	204-232-3

Quality Control

Our Cinchonine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and industrial use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-109° to -113° (c=1 in EtOH)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Chiral Purity (HPLC)	≥99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.