Description

Protoveratrine B CAS NO 124-97-0 is a potent, naturally occurring steroidal alkaloid ester derived from plants of the *Veratrum* genus. This compound serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for research and development in the life sciences. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular research, neuropharmacology, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of veratrum alkaloids in drug substances and finished products via HPLC, LC-MS, and other analytical methods.
• Cardiovascular Research: Employed as a research chemical to study its effects on blood pressure and ion channel activity due to its historical use as an antihypertensive agent.
• Neuropharmacology Studies: Utilized in neuroscience research to investigate its interaction with neuronal sodium channels and its potential effects on nerve signal transmission.
• API Intermediate: Acts as a key starting material or intermediate in the synthetic pathway for more complex pharmaceutical compounds.
• Biochemical Assay Development: Serves as a precise reagent in developing and validating assays for toxicity screening or pharmacological profiling.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in natural product chemistry and medicinal chemistry.

Basic Information

Product Name	Protoveratrine B
CAS No.	124-97-0
Molecular Formula	C41H63NO13
Molecular Weight	801.94 g/mol
Synonyms	Protoveratrine B; Veratetrine; 3,4,12,14,16,17,20-Heptahydroxy-4,9-epoxycevan-6-one 3,4-diacetate 12,14,16-tri(2-methylbutanoate); NSC 129943; Protoveratrine B (alkaloid); Veratrum alkaloid B; Ceva-16,20:22,26-diepoxy-3β,4β,14α,15α,16β,20-hexol 3,4-diacetate 14,15,16-tri(2-methylbutyrate)
EINECS	Contact for details

Quality Control

Our Protoveratrine B is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents to ensure it meets stringent specifications for research and pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.