Description

Sinomenine CAS NO 115-53-7 is a bioactive isoquinoline alkaloid primarily extracted from the roots and stems of the Chinese medicinal plant *Sinomenium acutum*. This compound is of significant commercial and research interest due to its well-documented anti-inflammatory and immunomodulatory properties. It serves as a critical intermediate and reference standard for the pharmaceutical, biotechnology, and nutraceutical industries, supporting the development of novel therapeutics and high-purity supplements.

Application

• Pharmaceutical Intermediate: A key starting material for the synthesis of advanced anti-rheumatic and immunosuppressive drug candidates.
• Reference Standard: Used in analytical laboratories for quality control, method validation, and quantification in herbal extracts and finished products via HPLC or LC-MS.
• Biomedical Research: Employed in *in vitro* and *in vivo* studies to investigate mechanisms of inflammation, autoimmune diseases, and neuropathic pain.
• Nutraceutical Formulations: Incorporated into high-end dietary supplements targeting joint health and inflammatory response modulation.
• Cosmeceutical Actives: Explored in topical formulations for its potential soothing and anti-irritant effects on the skin.

Basic Information

Product Name	Sinomenine
CAS No.	115-53-7
Molecular Formula	C19H23NO4
Molecular Weight	329.39 g/mol
Synonyms	Coculine; Sinomenin; Kukoline; 7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9α,13α,14α-morphinan-6-one; (9α,13α,14α)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
EINECS	204-096-2

Quality Control

Our Sinomenine is manufactured under a strict quality management system. Each batch is subjected to comprehensive identity, purity, and impurity profile testing using advanced analytical techniques including HPLC, GC, and NMR to ensure it meets stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with relevant standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.