Description

Muscimol Hydrate is a naturally occurring psychoactive isoxazole alkaloid, primarily known as the principal bioactive component of the mushroom *Amanita muscaria*. This compound is a potent and selective agonist for the GABAA receptor, making it a critical reference standard and research tool in neuropharmacology and neuroscience. It is essential for researchers and manufacturers in the pharmaceutical and life sciences sectors studying GABAergic neurotransmission, receptor function, and the development of novel neuroactive compounds.

Application

• Pharmacological Research: A key reference standard for studying GABAA receptor subtypes, their activation mechanisms, and downstream neurological effects.
• Neuroscience Studies: Used in vitro and in vivo models to investigate sedation, muscle relaxation, and the modulation of neuronal excitability.
• Analytical Chemistry: Serves as a high-purity certified reference material (CRM) for method development and validation in HPLC, LC-MS, and GC-MS analyses.
• Biochemical Assay Development: Employed as a precise tool in high-throughput screening (HTS) assays to identify and characterize new GABAergic drugs or neurotoxins.
• Toxicology & Forensic Science: Used as an analytical standard for the detection and quantification of muscimol in biological samples and forensic investigations.

Basic Information

Product Name	Muscimol Hydrate
CAS No.	18174-72-6
Molecular Formula	C4H6N2O2 • xH2O
Molecular Weight	114.10 g/mol (anhydrous basis)
Synonyms	5-(Aminomethyl)-3-isoxazolol Hydrate; Agarin; Pantherine; 3-Hydroxy-5-aminomethylisoxazole Hydrate; Muscimol Monohydrate; GABAA Receptor Agonist; (3-Hydroxyisoxazol-5-yl)methylamine Hydrate
EINECS	Contact for details

Quality Control

Our Muscimol Hydrate is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for reference materials, ensuring data integrity and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.