Description

(R)-(-)-Nifenalol CAS NO 5302-35-2 is a high-purity chiral β-adrenergic blocking agent, specifically the (R)-enantiomer of nifenalol. This compound is a critical chiral intermediate and reference standard in pharmaceutical research and development, particularly for studying stereoselective drug action and metabolism. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require enantiomerically pure building blocks for active pharmaceutical ingredient (API) synthesis and advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure β-blocker APIs and other cardiovascular drugs.
• Pharmacological Research: Used as a reference standard and tool compound in studies of β-adrenergic receptor binding, selectivity, and stereospecific activity.
• Chiral Catalyst/ Ligand Development: Serves as a precursor or scaffold for developing novel chiral catalysts and ligands in asymmetric synthesis.
• Analytical Standard: Provides a high-purity standard for method development and validation in chiral HPLC and other analytical techniques.
• Agrochemical Research: Investigated as an intermediate for developing chiral agrochemicals with improved efficacy and environmental profiles.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for fundamental studies in medicinal chemistry and stereochemistry.

Basic Information

Product Name	(R)-(-)-Nifenalol
CAS No.	5302-35-2
Molecular Formula	C12H16N2O3
Molecular Weight	236.27 g/mol
Synonyms	(R)-(-)-Nifenalol; (R)-Nifenalol; (R)-1-(4-Nitrophenyl)-2-(tert-butylamino)ethanol; (R)-α-[(tert-Butylamino)methyl]-4-nitrobenzenemethanol; (R)-(-)-1-(4-Nitrophenyl)-2-(tert-butylamino)ethanol; (R)-Bunitrolol Impurity; (R)-(-)-Bunitrolol Related Compound A; (R)-Form of Nifenalol
EINECS	Contact for details

Quality Control

Our (R)-(-)-Nifenalol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.