Description

21-Acetoxy-6α-Fluoro-16α,17-(Isopropylidenedioxy)Pregna-1,4,9(11)-Triene-3,20-Dione is a high-purity, synthetic steroid derivative with a complex molecular structure designed for advanced pharmaceutical research and development. This compound serves as a critical key intermediate in the synthesis of potent glucocorticoid and anti-inflammatory agents, offering researchers precise control over steroidal activity and metabolism. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation therapeutic steroids.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs, such as advanced glucocorticoid receptor agonists.
• Steroid Research: Used in academic and industrial research to study structure-activity relationships (SAR) of modified pregnane derivatives.
• Process Chemistry: Serves as a critical intermediate in the scale-up and process optimization for the manufacture of specialty steroid APIs (Active Pharmaceutical Ingredients).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in steroid analysis via HPLC or LC-MS.
• Biochemical Tool Compound: Utilized in preclinical studies to investigate the effects of fluorinated and acetoxylated steroids on specific metabolic pathways.

Basic Information

Product Name	21-Acetoxy-6α-Fluoro-16α,17-(Isopropylidenedioxy)Pregna-1,4,9(11)-Triene-3,20-Dione
CAS No.	5049-89-8
Molecular Formula	C₂₆H₃₁FO₆
Molecular Weight	458.52 g/mol
Synonyms	6α-Fluoro-16α,17α-Isopropylidenedioxy-21-acetoxypregna-1,4,9(11)-triene-3,20-dione; 6α-Fluoro-16α,17α-[(1-methylethylidene)bis(oxy)]-21-(acetyloxy)pregna-1,4,9(11)-triene-3,20-dione; 21-Acetoxy-6α-fluoro-16α,17α-isopropylidenedioxypregna-1,4,9(11)-triene-3,20-dione; 6α-Fluoro-16α,17α-acetonide-21-acetate of 9,11-dehydrocortexolone; 9,11-Dehydrocortexolone 6α-fluoro-16α,17α-acetonide 21-acetate; A Fluorinated Steroid Acetonide Intermediate.
EINECS	Contact for details

Quality Control

Our 21-Acetoxy-6α-Fluoro-16α,17-(Isopropylidenedioxy)Pregna-1,4,9(11)-Triene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.