Description

6Alpha-Fluoroprednisolone Acetate is a synthetic fluorinated corticosteroid derivative, a key intermediate in the synthesis of potent anti-inflammatory and immunosuppressive pharmaceutical agents. Its value lies in its role as a critical building block for advanced steroid-based therapeutics, offering a pathway to enhanced drug potency and metabolic stability. This compound is essential for pharmaceutical R&D laboratories and manufacturers specializing in the production of high-potency corticosteroids for treating severe inflammatory and autoimmune conditions.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of potent topical and systemic corticosteroid drugs.
• Anti-inflammatory Drug Synthesis: Used in the research and production of medications for conditions like dermatitis, psoriasis, and arthritis.
• Immunosuppressive Agent Development: Serves as a starting material for drugs used to prevent organ transplant rejection and treat autoimmune diseases.
• Steroid Chemistry Research: A valuable reference standard and reagent in academic and industrial research exploring structure-activity relationships of fluorinated steroids.
• Veterinary Pharmaceutical Manufacturing: Employed in the synthesis of anti-inflammatory treatments for animals.
• Advanced Drug Delivery Systems: Investigated for use in creating prodrugs or targeted delivery formulations to improve therapeutic profiles.

Basic Information

Product Name	6Alpha-Fluoroprednisolone Acetate
CAS No.	570-36-5
Molecular Formula	C23H29FO6
Molecular Weight	420.47 g/mol
Synonyms	6α-Fluoroprednisolone 21-Acetate; 6α-Fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-Acetate; 6α-Fluoroprednisolone Acetate; 6α-Fluoro-δ1-hydrocortisone Acetate; 6α-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; Fluorprednisolone Acetate (6α-isomer); 6α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoroprednisolone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.