Description

Meclozine is a piperazine-derivative antihistamine known for its specific pharmacological activity. This compound is critical for its antiemetic and antinauseant properties, making it a key active pharmaceutical ingredient (API) in therapeutic formulations. It is primarily required by the pharmaceutical industry for the manufacture of medications targeting motion sickness, vertigo, and nausea associated with various conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter antiemetic tablets and capsules.
• Motion Sickness Prevention: Formulation into medications for the prevention and treatment of nausea, vomiting, and dizziness caused by motion.
• Vertigo Management: Used in drugs designed to alleviate symptoms of vestibular disorders, such as Ménière's disease.
• Research & Development: Serves as a reference standard and building block in pharmacological research and new drug development.
• Veterinary Pharmaceuticals: Application in veterinary medicine for managing nausea and vestibular issues in animals.

Basic Information

Product Name	Meclozine
CAS No.	569-65-3
Molecular Formula	C25H27ClN2
Molecular Weight	390.95 g/mol
Synonyms	Meclizine; Meclozine Hydrochloride (salt form); Postafen; Bonine; Antivert; 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; Piplizine; Chlorazine; Histamethizine; Itimerol
EINECS	209-312-6

Quality Control

Our Meclozine is manufactured and tested to meet stringent pharmacopeial standards. Quality is assured through a comprehensive analytical regime including HPLC, IR, and loss on drying. A Certificate of Analysis (COA) is provided with each batch, confirming compliance with specifications for identity, purity, and related substances. We support audits and can supply documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.