Description

5B-Pregnane-11B,21-Diol-3,20-Dione CAS NO 566-01-8 is a high-purity steroid intermediate of significant importance in pharmaceutical synthesis. This compound serves as a critical building block for the production of more complex corticosteroid and other steroidal active pharmaceutical ingredients (APIs). It is essential for research and manufacturing organizations in the global pharmaceutical and biotechnology sectors that require reliable, high-quality raw materials for advanced drug development and production.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of corticosteroid drugs, including hydrocortisone and its derivatives.
• API Synthesis: Used in the research and commercial manufacturing of steroidal Active Pharmaceutical Ingredients (APIs) for anti-inflammatory and immunosuppressive therapies.
• Biochemical Research: Employed as a reference standard or starting material in steroid metabolism studies and endocrine research.
• Process Development: Utilized by process chemistry teams to develop and optimize scalable synthetic routes for complex steroid molecules.
• Custom Synthesis: Serves as a foundational compound for the custom synthesis of novel steroid analogs in medicinal chemistry programs.

Basic Information

Product Name	5B-Pregnane-11B,21-Diol-3,20-Dione
CAS No.	566-01-8
Molecular Formula	C21H32O4
Molecular Weight	348.48 g/mol
Synonyms	11B,21-Dihydroxypregnane-3,20-dione; 11B,21-Dihydroxy-5B-pregnane-3,20-dione; 5B-Pregnan-11B,21-diol-3,20-dione; Reichstein's Substance S Dihydro; 11B,21-Dihydroxy-5B-pregnan-3,20-dione; 11B,21-Dihydroxy-5B-pregnane-3,20-dione; 5B-Pregnane-11B,21-diol-3,20-dione
EINECS	Contact for details

Quality Control

Our 5B-Pregnane-11B,21-Diol-3,20-Dione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR), to ensure it meets exacting standards suitable for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.