Description

6-Dehydrofluorocortisol Acetate is a synthetic fluorinated corticosteroid derivative, a key intermediate in the synthesis of more complex steroid-based pharmaceuticals. Its value lies in its specific molecular structure, which is engineered to enhance biological activity and metabolic stability for research and development purposes. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel anti-inflammatory agents, dermatological treatments, and other steroid hormone analogues.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Research & Development: Used in medicinal chemistry programs to study structure-activity relationships (SAR) of fluorinated steroids.
• Reference Standard: Serves as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor binding and metabolic pathways.
• Process Development: Utilized for scaling up and optimizing synthetic routes for advanced steroid APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	6-Dehydrofluorocortisol Acetate
CAS No.	564-57-8
Molecular Formula	C23H29FO6
Molecular Weight	420.47 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate; 9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 6-Dehydro-9α-fluorohydrocortisone 21-acetate; Fludrocortisone acetate impurity; 9α-Fluoroprednisolone 21-acetate (related); 1,4-Pregnadiene-9α-fluoro-11β,17α,21-triol-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 6-Dehydrofluorocortisol Acetate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.