Description

Doxylamine Succinate CAS NO 562-10-7 is a white to off-white crystalline powder belonging to the ethanolamine class of antihistamines. It is a critical active pharmaceutical ingredient (API) valued for its potent sedative and antiemetic properties. This compound is essential for manufacturers in the pharmaceutical industry, particularly for formulating over-the-counter sleep aids, nighttime cold/flu medications, and anti-nausea preparations.

Application

• Pharmaceutical API: Primary use as the active ingredient in sedative-hypnotic medications for the short-term treatment of insomnia.
• Nighttime Formulations: Key component in multi-symptom nighttime cold, cough, and flu relief products for its sedating effect.
• Antiemetic Preparations: Used in formulations to prevent and treat nausea and vomiting, including morning sickness (under medical supervision).
• Veterinary Medicine: Employed in certain veterinary applications as a sedative or antiemetic for animals.
• Research & Development: Serves as a reference standard and building block in pharmacological and biochemical research.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for generic drug production.

Basic Information

Product Name	Doxylamine Succinate
CAS No.	562-10-7
Molecular Formula	C17H22N2O · C4H6O4
Molecular Weight	388.46 g/mol
Synonyms	Doxylamine Hydrogen Succinate; 2-[α-[2-(Dimethylamino)ethoxy]-α-methylbenzyl]pyridine hydrogen succinate; Histadoxylamine Succinate; UNII-95QB77JKMS; Decapryn Succinate; Meractin Succinate; C17H22N2O.C4H6O4; (RS)-N,N-Dimethyl-2-(1-phenyl-1-pyrid-2-ylethoxy)ethanamine succinate
EINECS	209-222-2

Quality Control

Our Doxylamine Succinate is manufactured under strict quality systems. It can be supplied to meet various pharmacopoeial standards, including USP, EP, and BP monographs. Every batch undergoes rigorous analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.