Description

Triprolidine Hydrochloride is a high-purity pharmaceutical active ingredient and a potent, selective histamine H1-receptor antagonist. Its primary value lies in its efficacy as an antihistamine, making it a critical component in the formulation of medications designed to alleviate allergy symptoms. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing anti-allergic and cold/flu remedies. We supply it in various grades to meet the stringent requirements of global regulatory standards for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter antihistamine medications.
• Allergy Relief Formulations: Key component in tablets, syrups, and capsules for treating symptoms of hay fever, allergic rhinitis, and urticaria.
• Cold and Flu Preparations: Used in combination with decongestants and analgesics in multi-symptom relief products.
• Veterinary Pharmaceuticals: Application in antihistamine treatments for animals.
• Biochemical Research: Used as a reference standard and in pharmacological studies of histamine receptors and allergic response pathways.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control laboratories.

Basic Information

Product Name	Triprolidine Hydrochloride
CAS No.	550-70-9
Molecular Formula	C19H22N2 • HCl
Molecular Weight	314.85 g/mol
Synonyms	(E)-1-(4-Methylphenyl)-1-(2-pyridinyl)-3-pyrrolidin-1-yl-prop-1-ene hydrochloride; Triprolidine HCl; Actidil; Actifed; Pro-Actidil; Baynas; 2-[1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine hydrochloride
EINECS	208-983-8

Quality Control

Our Triprolidine Hydrochloride is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical testing to ensure it meets the highest standards of identity, purity, and strength. We can supply material compliant with various pharmacopoeial monographs, including USP and EP. A detailed Certificate of Analysis (COA) documenting purity, related substances, residual solvents, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.