Description

Triprolidinehcl CAS NO 520-70-9 is the hydrochloride salt of triprolidine, a well-characterized pharmaceutical compound. It is a potent, selective histamine H1-receptor antagonist, valued for its efficacy in managing allergic responses. This active pharmaceutical ingredient (API) is primarily required by manufacturers in the pharmaceutical industry for the formulation of antihistamine medications.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in antihistamine tablet and capsule formulations.
• Key component in cold and allergy relief medications, often in combination with decongestants.
• Used in veterinary pharmaceutical preparations for treating allergic conditions in animals.
• Intermediate in pharmaceutical research and development for new therapeutic agents.
• Reference standard in analytical laboratories for quality control and method validation.
• Starting material for the synthesis of more complex drug derivatives in medicinal chemistry.

Basic Information

Product Name	Triprolidinehcl
CAS No.	520-70-9
Molecular Formula	C19H22N2•HCl
Molecular Weight	314.85 g/mol
Synonyms	Triprolidine Hydrochloride; (±)-Triprolidine Hydrochloride; (E)-Triprolidine Hydrochloride; trans-Triprolidine Hydrochloride; 2-[1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine Hydrochloride; Actidil Hydrochloride; Actifed (component); Baynasyn; Pro-Actidil; C19H22N2.HCl
EINECS	208-300-6

Quality Control

Our Triprolidine Hydrochloride is manufactured under strict quality management systems. It is tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with common pharmacopeial requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.