Description

Allopregnanolone is a potent endogenous neurosteroid and a key metabolite of progesterone, playing a crucial role in modulating neuronal excitability. Its primary value lies in its potent positive allosteric modulation of GABAA receptors, which underpins its significant neuropharmacological effects. This makes it a compound of high interest for research and development in the pharmaceutical and life science sectors, particularly for studies related to neurological and psychiatric conditions.

Application

• Neuroscience Research: As a reference standard and active compound in studies investigating GABAergic neurotransmission, neurosteroid action, and neuronal plasticity.
• Pharmacological Development: A critical intermediate and active pharmaceutical ingredient (API) in the development of novel therapeutics for conditions like postpartum depression, epilepsy, and anxiety disorders.
• Biochemical Analysis: Used as a high-purity standard in analytical methods such as HPLC, LC-MS, and GC-MS for the quantification of neurosteroids in biological matrices.
• Endocrinology Studies: Employed in research to understand the interplay between steroid hormones and the central nervous system.
• Cell Culture & In Vitro Models: Applied in experimental models to study its effects on neuronal cell function, survival, and response to stress.

Basic Information

Product Name	Allopregnanolone
CAS No.	516-55-2
Molecular Formula	C21H34O2
Molecular Weight	318.49 g/mol
Synonyms	3α-Hydroxy-5α-pregnan-20-one; 5α-Pregnan-3α-ol-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP; Brexanolone (pharmaceutical name); Pregnanolone (isomer); Allopregnanolone; (3α,5α)-3-Hydroxypregnan-20-one
EINECS	208-227-3

Quality Control

Our Allopregnanolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced chromatographic and spectroscopic techniques to ensure it meets stringent specifications for research and development use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.