Description

Pregnan-20-One, 3,17,21-Trihydroxy-, (3.Beta.,5.Alpha.)- is a key steroid intermediate, also known as Tetrahydrocortisone, with significant relevance in pharmaceutical synthesis. This compound is valued for its role as a versatile precursor in the production of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for the development and production of corticosteroids and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of corticosteroid drugs such as hydrocortisone and its derivatives.
• Biochemical Research: Used as a reference standard or starting material in metabolic pathway studies and steroid hormone research.
• Fine Chemical Synthesis: Serves as a building block for creating novel steroid analogs with potential therapeutic applications.
• API Development: Employed in process development and scale-up for the manufacture of steroid-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Pregnan-20-One, 3,17,21-Trihydroxy-, (3.Beta.,5.Alpha.)-
CAS No.	516-47-2
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	Tetrahydrocortisone; 5α-Tetrahydrocortisone; 3β,17α,21-Trihydroxy-5α-pregnan-20-one; 5α-Pregnane-3β,17α,21-triol-20-one; 3β,17α,21-Trihydroxy-5α-pregnan-20-one; Urocortisone; (3β,5α)-Pregnane-3,17,21-triol-20-one; 5α-THC
EINECS	208-229-9

Quality Control

Our Pregnan-20-One, 3,17,21-Trihydroxy-, (3.Beta.,5.Alpha.)- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.