Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(3,3-Dimethylbutyrate) CAS NO 508-96-3 is a key synthetic corticosteroid intermediate, specifically a 21-ester derivative of hydrocortisone. This compound is valued for its role in the targeted synthesis of more potent and specialized anti-inflammatory pharmaceutical agents. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of advanced topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of more complex corticosteroid drugs, including prodrugs and derivatives with enhanced activity or delivery profiles.
• Anti-inflammatory Drug Research: Used in the research and development of novel glucocorticoid receptor agonists for treating inflammatory and autoimmune conditions.
• Dermatological Preparations: Serves as a precursor in the manufacture of topical corticosteroids used for eczema, psoriasis, and dermatitis.
• Steroid Prodrug Development: The 21-(3,3-dimethylbutyrate) ester group is a strategic modification to alter the pharmacokinetics, such as lipophilicity and hydrolysis rate, of the parent steroid.
• Biochemical Research: Employed in studies investigating steroid metabolism, receptor binding, and the structure-activity relationships (SAR) of corticosteroids.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(3,3-Dimethylbutyrate)
CAS No.	508-96-3
Molecular Formula	C27H40O6
Molecular Weight	460.60 g/mol
Synonyms	Hydrocortisone 21-(3,3-Dimethylbutyrate); Cortisol 21-(3,3-Dimethylbutyrate); 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(3,3-dimethylbutyrate); 21-(3,3-Dimethylbutyryloxy)-11β,17α-dihydroxypregn-4-ene-3,20-dione; 21-Tigloylhydrocortisone (obsolete); Hydrocortisone 21-tiglate; NSC 113935
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(3,3-Dimethylbutyrate) is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.