Description

17α,21-Dihydroxypregn-4-Ene-3,11,20-Trione 21-Phosphate is a key synthetic intermediate in the production of corticosteroid pharmaceuticals. This compound matters for its role as a crucial precursor in the synthesis of potent anti-inflammatory and immunosuppressive agents, ensuring high-purity starting materials for complex drug manufacturing. Pharmaceutical research and development laboratories, as well as fine chemical manufacturers, require this high-quality intermediate to support the production of advanced steroid-based therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the multi-step synthesis of corticosteroid drugs such as hydrocortisone and its derivatives.
• Steroid Hormone Research: Serves as a reference standard and starting material in biochemical research focused on adrenal cortex hormones and their metabolic pathways.
• Fine Chemical Synthesis: Utilized in custom synthesis and process development for creating novel steroid analogs with potential therapeutic applications.
• Active Pharmaceutical Ingredient (API) Development: A key precursor in the development and scale-up manufacturing processes for corticosteroid APIs.

Basic Information

Product Name	17α,21-Dihydroxypregn-4-Ene-3,11,20-Trione 21-Phosphate
CAS No.	508-95-2
Molecular Formula	C21H29O8P
Molecular Weight	440.42 g/mol
Synonyms	Cortisone 21-Phosphate; 11-Dehydrocorticosterone 21-Phosphate; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-(dihydrogen phosphate); Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-(dihydrogen phosphate); Cortisone Phosphate; NSC 113935
EINECS	Contact for details

Quality Control

Our 17α,21-Dihydroxypregn-4-Ene-3,11,20-Trione 21-Phosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.