Description

Pronetalol CAS NO 54-80-8 is a high-purity chemical compound, also known as pronethalol, belonging to the class of β-adrenergic blocking agents. This compound is of significant interest in pharmaceutical research and development, particularly for its historical and structural relevance in the study of cardiovascular therapeutics. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical and fine chemical industries, where precise chemical structure and purity are paramount for developing new active pharmaceutical ingredients (APIs) and conducting pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex β-blocker drug candidates and related pharmacologically active molecules.
• Research & Development: Used as a reference standard and biochemical tool in cardiovascular research to study β-adrenergic receptor mechanisms and drug-receptor interactions.
• Analytical Standard: Employed in analytical laboratories for method development, calibration, and quality control testing in pharmaceutical analysis using techniques like HPLC and LC-MS.
• Academic Studies: Utilized in university and institutional research for teaching and investigating the structure-activity relationships (SAR) of early generation β-blockers.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs) producing tailored compounds for clinical trials.

Basic Information

Product Name	Pronetalol
CAS No.	54-80-8
Molecular Formula	C₁₄H₂₁NO₂
Molecular Weight	235.33 g/mol
Synonyms	Pronethalol; N-Isopropylnorepinephrine; 1-(2-Naphthyl)-2-isopropylaminoethanol; 2-(Isopropylamino)-1-(2-naphthyl)ethanol; AY-62013; ICI 38174; Nethalide; Alderlin
EINECS	200-206-5

Quality Control

Our Pronetalol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) that include results from advanced techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.