Description

Fluprednisolone is a synthetic fluorinated glucocorticoid corticosteroid, distinguished by its potent anti-inflammatory and immunosuppressive properties. This compound is critical for pharmaceutical manufacturers requiring high-purity active pharmaceutical ingredients (APIs) for advanced therapeutic formulations. It is primarily utilized in the development of prescription medications targeting severe inflammatory and autoimmune conditions, offering a powerful tool for modern pharmacotherapy.

Application

• Pharmaceutical API: Core active ingredient in prescription anti-inflammatory and immunosuppressive drugs.
• Dermatological Preparations: Used in creams and ointments for treating severe skin conditions like psoriasis, eczema, and contact dermatitis.
• Ophthalmic Solutions: Formulated into eye drops to manage inflammatory eye disorders such as uveitis and allergic conjunctivitis.
• Systemic Corticosteroid Therapy: Employed in oral or injectable formulations for managing autoimmune diseases, including rheumatoid arthritis and lupus.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for treating inflammation and immune-mediated diseases in animals.
• Research & Development: Serves as a reference standard and key intermediate in biochemical research and new drug discovery programs.

Basic Information

Product Name	Fluprednisolone
CAS No.	53-34-9
Molecular Formula	C₂₁H₂₇FO₅
Molecular Weight	378.44 g/mol
Synonyms	6α-Fluoroprednisolone; 6α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; Alphadrol; 6α-Fluoro-δ¹-hydrocortisone; NSC-47439; Fluprednisolonum; Fluprednisolona
EINECS	200-173-7

Quality Control

Our Fluprednisolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) documenting full compliance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Specific Rotation	+108° to +118° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.