Description

Paramethasone CAS NO 53-33-8 is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. This compound is a critical active pharmaceutical ingredient (API) for the formulation of specialized pharmaceutical products. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of treatments for severe inflammatory and autoimmune conditions, as well as in advanced biochemical research.

Application

• Primary Active Pharmaceutical Ingredient (API) in corticosteroid formulations.
• Research and development of anti-inflammatory and immunosuppressive therapies.
• Manufacturing of injectable or topical pharmaceutical preparations for dermatological use.
• Key intermediate in advanced organic synthesis for novel steroid-based compounds.
• Reference standard in analytical laboratories for quality control and method development.
• Biochemical research focusing on glucocorticoid receptor activity and signaling pathways.

Basic Information

Product Name	Paramethasone
CAS No.	53-33-8
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	6α-Fluoro-16α-methylprednisolone; 6α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 6α-Fluoro-16α-methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione; Paramethasone Base; NSC-92339; Monocortin; Dilar; Haldidrone; Metilar
EINECS	200-173-8

Quality Control

Our Paramethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥98% by HPLC), and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.