Description

3Alpha,17,21-Trihydroxy-5-β-Pregnane-11,20-Dione is a key steroid intermediate with significant pharmaceutical relevance. This compound is valued for its role as a versatile precursor in the synthesis of various corticosteroid and other bioactive steroid molecules. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of steroid-based active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of corticosteroids such as hydrocortisone and its derivatives.
• Steroid API Production: Used in the manufacturing process of various steroid-based active pharmaceutical ingredients.
• Biochemical Research: Serves as a reference standard and starting material in metabolic pathway studies and steroid biochemistry research.
• Process Development: Utilized in the development and optimization of synthetic routes for complex steroid molecules in pilot-scale and commercial production.

Basic Information

Product Name	3Alpha,17,21-Trihydroxy-5-β-Pregnane-11,20-Dione
CAS No.	53-05-4
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	11-Deoxycortisol; 17,21-Dihydroxypregn-4-ene-3,20-dione; Reichstein's Substance S; 17α,21-Dihydroxy-4-pregnene-3,20-dione; Cortodoxone; 11-Deoxy-17-hydroxycorticosterone; 21-Hydroxyprogesterone
EINECS	200-166-3

Quality Control

Our 3Alpha,17,21-Trihydroxy-5-β-Pregnane-11,20-Dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.