Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic corticosteroid derivative, recognized for its potent anti-inflammatory and immunosuppressive activity. This compound is a critical pharmaceutical intermediate in the synthesis of advanced topical and systemic corticosteroid medications. It is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring reliable, high-quality raw materials for API production.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key building block in the synthesis of potent topical corticosteroids like difluprednate and other fluorinated steroid drugs.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing new anti-inflammatory and immunosuppressive therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Fine Chemical Synthesis: Employed in custom synthesis and the production of specialized steroid analogs for research purposes.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	52-70-0
Molecular Formula	C23H28F2O6
Molecular Weight	438.47 g/mol
Synonyms	Difluprednate Intermediate; 6α,9α-Difluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate (related isomer); 21-Acetoxy-6α,9α-difluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione; Fluorinated Corticosteroid Acetate; NSC 47439
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing including HPLC, IR, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.