Description

Prednisolone-21-Acetate is a synthetic glucocorticoid corticosteroid and a key pharmaceutical intermediate. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, serving as a crucial building block in the synthesis of advanced steroid medications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for conditions such as allergies, inflammation, and autoimmune diseases.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of finished corticosteroid drug products and injectable formulations.
• Anti-inflammatory Drug Production: A key precursor for manufacturing potent topical and systemic anti-inflammatory medications.
• Immunosuppressive Therapy: Used in the development of drugs for managing autoimmune disorders and preventing organ transplant rejection.
• Research & Development: Serves as a reference standard and active material in pharmacological and biochemical research studies.
• Veterinary Pharmaceuticals: Employed in formulating anti-inflammatory and anti-allergic treatments for animal healthcare.
• Ophthalmic Preparations: Used in the production of steroid eye drops and ointments for treating ocular inflammation.

Basic Information

Product Name	Prednisolone-21-Acetate
CAS No.	52-21-1
Molecular Formula	C23H30O6
Molecular Weight	402.48 g/mol
Synonyms	21-Acetoxyprednisolone; Prednisolone Acetate; 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 1,4-Pregnadiene-3,20-dione, 11,17,21-trihydroxy-, 21-acetate; NSC-527579; Sterane; δ-Cortef Acetate; Metacortandralone Acetate
EINECS	200-127-3

Quality Control

Our Prednisolone-21-Acetate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, IR, and loss on drying, to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to ensure traceability and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+112° to +122° (c=1 in dioxane)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.