Description

Actinomycin D CAS NO 50-76-0 is a potent polypeptide antibiotic isolated from *Streptomyces* bacteria, functioning as a transcription inhibitor by binding to DNA. This compound is critically important in biochemical and pharmaceutical research for its role in studying transcription mechanisms and as a reference standard. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in oncology research, molecular biology studies, and the quality control of related pharmaceutical products.

Application

• Biochemical Research: Used as a specific inhibitor of DNA-dependent RNA synthesis to study transcription and gene expression mechanisms.
• Oncology Research: Serves as a reference compound and positive control in cancer biology studies, particularly for investigating apoptosis and chemotherapy mechanisms.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for the quality control and assay validation of pharmaceutical products containing actinomycin D.
• Molecular Biology: Applied in laboratory protocols to inhibit transcription, allowing for the isolation and study of other cellular processes.
• Antibiotic Research: Used in microbiological studies to understand the action of polypeptide antibiotics and explore potential derivatives.

Basic Information

Product Name	Actinomycin D
CAS No.	50-76-0
Molecular Formula	C62H86N12O16
Molecular Weight	1255.42 g/mol
Synonyms	Dactinomycin; Actinomycin IV; Actinomycin C1; Meractinomycin; Actinomycin AIV; Cosmegen; Actinomycin D1; NSC-3053; 2-Amino-N, N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-2,3,5,6,9,10,13,14,15,16-decahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
EINECS	200-063-6

Quality Control

Our Actinomycin D is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. Keep the container in a dry, well-ventilated place. Handle with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	-315° to -335° (c=0.25 in methanol)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.