Description

Cortisone Acetate CAS NO 50-04-4 is a synthetic glucocorticoid corticosteroid and a pharmaceutical intermediate of significant importance. This compound is a key precursor in the synthesis of various steroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: A critical starting material for the synthesis of hydrocortisone and other potent corticosteroid APIs.
• Anti-inflammatory Drug Production: Used in the manufacture of medications for treating conditions like rheumatoid arthritis, lupus, and severe allergies.
• Research & Development: Serves as a reference standard and building block in pharmacological and biochemical research on steroid hormone action.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for animals.
• Dermatological Preparations: A component in the development of topical creams and ointments for skin inflammation.
• Endocrine Disorder Research: Used in studies related to adrenal cortex function and corticosteroid replacement therapy.

Basic Information

Product Name	Cortisone Acetate
CAS No.	50-04-4
Molecular Formula	C23H30O6
Molecular Weight	402.49 g/mol
Synonyms	17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate; 11-Dehydro-17-hydroxycorticosterone 21-acetate; Cortisone 21-acetate; Adreson; Cortistab; Cortisyl acetate; Reichstein's Substance FA acetate; (11β)-17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate
EINECS	200-003-9

Quality Control

Our Cortisone Acetate is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure high purity and consistency, meeting the requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with each batch. We can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	+208° to +218° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.