Description

Hydrocortisone Acetate CAS NO 50-03-3 is a synthetic corticosteroid ester, widely recognized as a key active pharmaceutical ingredient (API) in the global pharmaceutical market. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a cornerstone in topical and injectable formulations. It is essential for manufacturers in the pharmaceutical and cosmetic industries developing treatments for dermatological conditions, allergies, and inflammatory disorders.

Application

• Topical Corticosteroid Creams and Ointments: Primary API for treating eczema, psoriasis, contact dermatitis, and other inflammatory skin conditions.
• Injectable Suspensions: Used in intra-articular or soft tissue injections for localized inflammation and pain relief, such as in bursitis or arthritis.
• Ophthalmic Preparations: Key ingredient in eye drops and ointments for treating inflammatory eye conditions like uveitis and allergic conjunctivitis.
• Veterinary Pharmaceuticals: Employed in topical and injectable formulations for treating inflammatory and allergic conditions in animals.
• Cosmetic & Dermatological Research: Serves as a reference standard and active component in R&D for new anti-inflammatory skincare products.
• Compounding Pharmacy: Used by pharmacists to prepare customized medication strengths and formulations for specific patient needs.

Basic Information

Product Name	Hydrocortisone Acetate
CAS No.	50-03-3
Molecular Formula	C23H32O6
Molecular Weight	404.50 g/mol
Synonyms	Cortisol Acetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate; 17-Hydroxycorticosterone 21-acetate; Hydrocortisone 21-Acetate; Cortef Acetate; Compound F Acetate; NSC 47439
EINECS	200-004-0

Quality Control

Our Hydrocortisone Acetate is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards including USP, EP, and BP. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Specific Rotation	+158° to +165°
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.