Description

2,4,5-Trifluoro-3-Bromonitrobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromo, nitro, and trifluoro substituents, makes it a versatile and reactive intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Serves as a building block for creating novel fluorinated liquid crystals, organic semiconductors, and polymers with tailored electronic and surface properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The electron-deficient aromatic ring, activated by nitro and fluorine groups, is highly reactive in nucleophilic substitution reactions for introducing diverse functional groups.
• Chemical Library Development: A valuable scaffold for medicinal chemistry and high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	2,4,5-Trifluoro-3-Bromonitrobenzene
CAS No.	485318-76-1
Molecular Formula	C6H2BrF3NO2
Molecular Weight	257.99 g/mol
Synonyms	3-Bromo-2,4,5-trifluoronitrobenzene; 1-Bromo-2,4,5-trifluoro-3-nitrobenzene; Benzene, 1-bromo-2,4,5-trifluoro-3-nitro-; 2,4,5-Trifluoro-3-nitro-1-bromobenzene; 3-Nitro-2,4,5-trifluorobromobenzene
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluoro-3-Bromonitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizers and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.