Description

1-(4-(Trifluoromethyl)Phenyl)Cyclopentanecarbonitrile is a high-value, fluorinated organic intermediate featuring a cyclopentane ring and a benzonitrile moiety. This compound is critical for its role in the synthesis of advanced pharmaceutical and agrochemical molecules, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its rigid, fluorinated aromatic structure.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	1-(4-(Trifluoromethyl)Phenyl)Cyclopentanecarbonitrile
CAS No.	483368-73-6
Molecular Formula	C13H12F3N
Molecular Weight	239.24 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]cyclopentanecarbonitrile; 4-(1-Cyanocyclopentyl)benzotrifluoride; α-(4-Trifluoromethylphenyl)cyclopentaneacetonitrile; Cyclopentanecarbonitrile, 1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethylphenyl)cyclopentane-1-carbonitrile; 483368-73-6; Benzene, 1-(1-cyanocyclopentyl)-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-(4-(Trifluoromethyl)Phenyl)Cyclopentanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support development under ICH guidelines and cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.