Description

2-Pyrrolidinecarbonitrile, 4,4-Difluoro-, (2S)- is a high-value, chiral fluorinated pyrrolidine derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and agrochemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates to construct complex, bioactive molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Research: Building block for developing new chiral herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective synthesis.
• Medicinal Chemistry: Employed in drug discovery programs for scaffold diversification and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Intermediate for the production of specialty chemicals, flavors, and fragrances requiring fluorinated chiral centers.
• Academic & R&D: Valuable reagent for methodological development in organic synthesis and fluorine chemistry at research institutions.

Basic Information

Product Name	2-Pyrrolidinecarbonitrile, 4,4-Difluoro-, (2S)-
CAS No.	483366-15-0
Molecular Formula	C5H6F2N2
Molecular Weight	132.11 g/mol
Synonyms	(2S)-4,4-Difluoropyrrolidine-2-carbonitrile; (S)-4,4-Difluoropyrrolidine-2-carbonitrile; 4,4-Difluoro-L-prolinenitrile; (S)-4,4-Difluoro-2-cyanopyrrolidine; L-4,4-Difluoropyrrolidine-2-carbonitrile; 4,4-Difluoropyrrolidine-2-carbonitrile, (S)-; 2-Cyano-4,4-difluoro-(S)-pyrrolidine; (2S)-4,4-Difluoro-2-pyrrolidinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonitrile, 4,4-Difluoro-, (2S)- is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing parameters such as assay, enantiomeric excess, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.