Description

3-[(4-Chlorobenzyl)Amino]-1,1,1-Trifluoro-2-Propanol is a specialized fluorinated amino alcohol building block of significant interest in advanced organic synthesis. This compound matters for its unique structural features, combining a chlorobenzyl group with a trifluoromethyl-substituted propanol backbone, which are valuable for modulating the physicochemical properties of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring metabolic stability.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, or insecticides where the fluorine and chlorine atoms contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty monomers to impart unique surface properties and chemical resistance.
• Chemical Biology Probe: Useful for creating tagged molecules or activity-based probes to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-[(4-Chlorobenzyl)Amino]-1,1,1-Trifluoro-2-Propanol
CAS No.	478081-30-0
Molecular Formula	C10H11ClF3NO
Molecular Weight	253.65 g/mol
Synonyms	1,1,1-Trifluoro-3-[(4-chlorophenyl)methyl]amino]-2-propanol; 3-[(4-Chlorobenzyl)amino]-1,1,1-trifluoropropan-2-ol; 1,1,1-Trifluoro-3-[(4-chlorobenzyl)amino]-2-propanol; 2-Propanol, 3-[(4-chlorobenzyl)amino]-1,1,1-trifluoro-; 4-Chloro-N-(1,1,1-trifluoro-2-hydroxy-3-propyl)benzylamine; α-(4-Chlorobenzyl)amino-β,β,β-trifluoroethanol
EINECS	Contact for details

Quality Control

Our 3-[(4-Chlorobenzyl)Amino]-1,1,1-Trifluoro-2-Propanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation by IR and NMR, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.