Description

2-(4-Methylphenoxy)-5-(Trifluoromethyl)Benzenecarbonitrile is a high-value, multi-functional aromatic nitrile derivative. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, prized for its unique trifluoromethyl and phenoxy substituents. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for the synthesis of advanced electronic materials, including liquid crystal display (LCD) components and organic light-emitting diode (OLED) emitters.
• Polymer & Resin Modifier: Employed to introduce specific functional groups into polymer chains, enhancing properties like thermal stability, chemical resistance, and optical characteristics.
• Organic Synthesis Reagent: Acts as a versatile synthon in cross-coupling reactions, nucleophilic aromatic substitution, and cyano-group transformations for creating complex molecular architectures.

Basic Information

Product Name	2-(4-Methylphenoxy)-5-(Trifluoromethyl)Benzenecarbonitrile
CAS No.	477867-25-7
Molecular Formula	C15H10F3NO
Molecular Weight	277.24 g/mol
Synonyms	5-(Trifluoromethyl)-2-(p-tolyloxy)benzonitrile; 2-(4-Methylphenoxy)-5-(trifluoromethyl)benzonitrile; 2-(p-Tolyloxy)-5-(trifluoromethyl)benzonitrile; Benzonitrile, 2-(4-methylphenoxy)-5-(trifluoromethyl)-; 2-(4-Methylphenoxy)-alpha,alpha,α-trifluoro-p-toluonitrile; 477867-25-7
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Methylphenoxy)-5-(Trifluoromethyl)Benzenecarbonitrile is manufactured under a cGMP-compliant quality management system. We employ rigorous analytical protocols including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.