Description

2-[(4-Fluorophenyl)Sulfanyl]-5-(Trifluoromethyl)Benzenecarbonitrile is a high-value, multi-functional organic intermediate characterized by its unique combination of fluorinated and sulfur-containing aromatic rings. This compound matters for its role as a critical building block in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structural motifs can impart desirable properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the trifluoromethyl and fluorophenyl groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Acts as a building block for creating advanced organic electronic materials due to its rigid, conjugated structure and fluorine atoms, which can influence charge transport and optical properties.
• Polymer Modification: Employed to introduce specific functional groups into polymer chains, enhancing properties such as chemical resistance, thermal stability, or surface characteristics.
• Ligand & Catalyst Development: Useful in organometallic chemistry for the design of novel ligands and catalysts used in cross-coupling and other catalytic transformations.
• Chemical Biology Probe Synthesis: Utilized in the creation of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	2-[(4-Fluorophenyl)Sulfanyl]-5-(Trifluoromethyl)Benzenecarbonitrile
CAS No.	477866-78-7
Molecular Formula	C14H7F4NS
Molecular Weight	297.27 g/mol
Synonyms	5-(Trifluoromethyl)-2-[(4-fluorophenyl)thio]benzonitrile; 2-((4-Fluorophenyl)thio)-5-(trifluoromethyl)benzonitrile; 2-[(4-Fluorophenyl)thio]-5-(trifluoromethyl)benzonitrile; Benzonitrile, 2-[(4-fluorophenyl)thio]-5-(trifluoromethyl)-; 2-(4-Fluorophenylsulfanyl)-5-trifluoromethylbenzonitrile; 2-(p-Fluorophenylthio)-5-(trifluoromethyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 2-[(4-Fluorophenyl)Sulfanyl]-5-(Trifluoromethyl)Benzenecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.