Description

5-(Chloromethyl)-2,2-Difluorobenzo[D][1,3]Dioxole is a high-value, multi-functional aromatic building block featuring a chloromethyl group and a difluorinated dioxole ring. This compound is critical for researchers and manufacturers requiring precise molecular architecture in advanced synthesis. It is primarily utilized in the pharmaceutical, agrochemical, and specialty materials industries for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of modern pesticides and herbicides, where the difluorinated moiety can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic electronic materials, contributing to improved performance and stability in displays and lighting.
• Polymer Modification: Acts as a reactive monomer or cross-linking agent to introduce functional groups into polymer backbones, altering physical and chemical properties.
• Organic Synthesis Building Block: The chloromethyl group offers a versatile handle for further functionalization via nucleophilic substitution, enabling rapid diversification of chemical libraries.

Basic Information

Product Name	5-(Chloromethyl)-2,2-Difluorobenzo[D][1,3]Dioxole
CAS No.	476473-97-9
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2,2-Difluoro-5-(chloromethyl)-1,3-benzodioxole; 5-(Chloromethyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-5-methyl chloride; 476473-97-9; 5-Chloromethyl-2,2-difluorobenzo[d][1,3]dioxole
EINECS	Contact for details

Quality Control

Our production of 5-(Chloromethyl)-2,2-Difluorobenzo[D][1,3]Dioxole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.