Description

21-Hemiacetal Dexamethasone is a key pharmaceutical intermediate and a derivative of the potent glucocorticoid dexamethasone. This compound is crucial for the synthesis of advanced steroid-based APIs, offering a strategic building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories focused on developing novel anti-inflammatory, immunosuppressive, and oncological therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of dexamethasone and its more potent analogs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to develop new glucocorticoid receptor modulators.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up processes for steroid-based APIs targeting inflammation and autoimmune disorders.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor signaling pathways and gene expression mechanisms.

Basic Information

Product Name	21-Hemiacetal Dexamethasone
CAS No.	473273-03-9
Molecular Formula	C22H29FO6
Molecular Weight	408.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetaldehyde; Dexamethasone 21-Hemiacetal; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione Cyclic 16,17-Acetal with Acetaldehyde; Dexamethasone Acetonide Related Compound; Dexamethasone 16,17-Acetonide Impurity
EINECS	Contact for details

Quality Control

Our 21-Hemiacetal Dexamethasone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.