Description

Benzene, 1,2-Difluoro-4-Isocyano- (9Ci) CAS NO 472958-69-3 is a specialized fluorinated aromatic isocyanide building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the isocyano group combined with the electronic influence of the fluorine substituents, enabling the construction of complex heterocyclic and pharmaceutical scaffolds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries seeking to innovate in drug discovery and functional material design.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating novel isocyanide-based ligands used in transition metal catalysis and organometallic chemistry.
• Heterocyclic Chemistry: Employed in multi-component reactions (MCRs), such as the Ugi and Passerini reactions, to efficiently generate diverse libraries of nitrogen-containing heterocycles for screening.
• Materials Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and bioconjugation reagents for studying biological processes.

Basic Information

Item	Detail
Product Name	Benzene, 1,2-Difluoro-4-Isocyano- (9Ci)
CAS No.	472958-69-3
Molecular Formula	C7H3F2N
Molecular Weight	139.11 g/mol
Synonyms	1,2-Difluoro-4-isocyanobenzene; 4-Isocyano-1,2-difluorobenzene; 1,2-Difluoro-4-isocyano-Benzene; 2,3-Difluorophenyl isocyanide; 3,4-Difluorophenyl isocyanide; (2,3-Difluorophenyl)isocyanide; (3,4-Difluorophenyl)isocyanide
EINECS	Contact for details

Quality Control

Our Benzene, 1,2-Difluoro-4-Isocyano- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature and reactive isocyano group, prolonged exposure to light, heat, or moisture should be avoided. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.