Description

3,5-Difluoro-4-formylbenzonitrile is a high-value, multi-functional aromatic building block characterized by its difluoro-substituted benzaldehyde core and a reactive nitrile group. This compound matters for its unique electronic and steric properties, making it an essential intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for constructing polar components in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs) due to its rigid, polarizable structure.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Cross-Coupling Reactions: The formyl and nitrile groups make it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions.
• Ligand & Catalyst Development: Utilized in the synthesis of novel chelating ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	3,5-Difluoro-4-formylbenzonitrile
CAS No.	467442-15-5
Molecular Formula	C8H3F2NO
Molecular Weight	167.11 g/mol
Synonyms	4-Cyano-2,6-difluorobenzaldehyde; 2,6-Difluoro-4-formylbenzonitrile; 2,6-Difluoro-4-cyanobenzaldehyde; 4-Formyl-3,5-difluorobenzonitrile; Benzonitrile, 3,5-difluoro-4-formyl-; 3,5-Difluorobenzaldehyde-4-carbonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-formylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.