Description

Benzenepropanenitrile, 2-Fluoro-α-Hydroxy- (9Ci) is a specialized fluorinated aromatic nitrile derivative, serving as a high-value synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring precise fluorination and functional group manipulation.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including potential kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Chemistry: Employed to introduce fluorinated side chains into polymers, modifying their surface properties and chemical resistance.
• Chemical Biology & Proteomics: Useful as a tagging or linking agent in the design of activity-based probes and bioconjugation reagents.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated benzonitrile motifs.

Basic Information

Product Name	Benzenepropanenitrile, 2-Fluoro-α-Hydroxy- (9Ci)
CAS No.	458528-60-4
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	2-Fluoro-α-hydroxybenzenepropanenitrile; 2-Fluoro-α-hydroxyhydrocinnamomitrile; (2-Fluorophenyl)(hydroxy)acetonitrile; α-Hydroxy-2-fluorobenzeneacetonitrile; 2-Fluoro-mandelonitrile; (RS)-2-Fluoro-2-phenyl-2-hydroxyacetonitrile; 458528-60-4; FCHN
EINECS	Contact for details

Quality Control

Our Benzenepropanenitrile, 2-Fluoro-α-Hydroxy- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP and ISO guidelines ensures material traceability and reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under dry, inert conditions to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.