Description

3,5-Dicyanofluorobenzene is a high-value fluorinated aromatic building block, essential for constructing complex molecular architectures in advanced research and development. Its unique structure, featuring both cyano and fluoro substituents, makes it a versatile precursor for synthesizing pharmaceuticals, agrochemicals, and functional materials. This compound is particularly sought after by R&D chemists and process development scientists in the pharmaceutical and specialty chemical industries for creating novel active ingredients and electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for electron-transport materials and host compounds in organic light-emitting diodes (OLEDs) and display technologies.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to improve thermal stability, chemical resistance, and dielectric properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive fluorine atom.
• Nucleophilic Aromatic Substitution: The fluorine atom is readily displaced by various nucleophiles, enabling efficient introduction of diverse functional groups.
• Chemical Research & Development: A valuable reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	3,5-Dicyanofluorobenzene
CAS No.	453565-55-4
Molecular Formula	C8H3FN2
Molecular Weight	146.12 g/mol
Synonyms	1-Fluoro-3,5-dicyanobenzene; 3,5-Dicyano-1-fluorobenzene; Benzene, 1-fluoro-3,5-dicyano-; 3-Fluoro-5-cyanobenzonitrile; 5-Fluoro-1,3-benzenedicarbonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Dicyanofluorobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.